A SINGLE-CHAIN-BASED HEXAVALENT CD27 AGONIST ENHANCES T CELL ACTIVATION AND INDUCES ANTI-TUMOR IMMUNITY

Tumor necrosis factor receptor superfamily member 7 (TNFRSF7, CD27), expressed primarily by T cells, and its ligand CD27L (TNFSF7, CD70) provide co-stimulatory signals that boost T cell activation, differentiation, and survival.Agonistic stimulation of CD27 is therefore a promising therapeutic concept in immuno-oncology intended to boost and sustai

IntroductionHypoxia-inducible factors (HIF) regulate gene transcription, which aids hypoxia adaptation while promoting renal fibrosis.Non-transferrin-bound iron (NTBI) is a catalytic form of iron that can lead to oxidative damage.However, NTBI in cat biofluids has ACTIVATED CHARCOAL FLOSS rarely been evaluated.AimsWe assessed cat plasma and urine H